Umjovo we-Enrofloxacin

I-Pharmacodynamic Enrofloxacin isidakamizwa esibulala amagciwane esibanzi esisetshenziswa ngokukhethekile ezilwaneni ze-fluoroquinolone.Okwe-e.coli, i-salmonella, i-klebsiella, i-brucella, i-pasteurella, i-pleuropneumonia actinobacillus, i-erysipelas, i-bacillus proteus, i-clayey amagciwane kaMnu Charest, i-suppurative corynebacterium, i-blood pott's bacterium, i-staphylococcus aureus, i-mycoplasma, njll. futhi i-streptococcus ibuthakathaka, umphumela obuthakathaka kubhaktheriya ye-anaerobic.Inomphumela osobala we-post-antibacterial kuma-bacteria azwelayo.Isenzo se-antibacterial salo mkhiqizo ukuvimbela ukujikeleza kwe-DNA yebhaktheriya, ukuphazamisa ukuphindaphinda, ukulotshwa kanye nokulungiswa kokuhlanganiswa kabusha kwe-DNA yebhaktheriya, amagciwane awakwazi ukukhula nokuzalana ngokujwayelekile futhi afe.

I-Pharmacokinetics Umuthi wamuncwa ngokushesha nangokuphelele ngomjovo we-intramuscular.I-bioavailability yayingama-91.9% ezingulubeni kanye nama-82% ezinkomeni.Isatshalaliswa kabanzi ezilwaneni futhi ingangena kahle ezicutshini nasemanzini omzimba.Ngaphandle koketshezi lwe-cerebrospinal, ukugcwala kwezidakamizwa cishe kuzo zonke izicubu kungaphezulu kwalokho ku-plasma.Umetabolism oyinhloko we-hepatic ukususwa kwe-ethyl ye-7-piperazine ring ukukhiqiza i-ciprofloxacin, kulandelwa i-oxidation ne-glucuronic acid ebophayo.Ikakhulukazi ngezinso (i-renal tubular secretion kanye nokuhlunga kwe-glomerular) ukuphuma, 15% ~ 50% ngesimo sokuqala esivela emchameni.Ukuqedwa kwesigamu sempilo yomjovo we-intramuscular kwaba amahora angu-5.9 ezinkomeni zobisi, amahora angu-1.5 ~ 4.5 ezimvini, namahora angu-4.6 ezingulubeni.